Enhanced Reductive Dechlorination (ERD) through biostimulation and redox manipulation is a well-established treatment method for chlorinated solvent contamination in groundwater. However, it is sometimes considered inappropriate where natural conditions are not already conducive to anaerobic attenuation, such as highly aerobic aquifers or fast-flowing groundwater. The use of microbial assays or PCR testing can potentially reinforce this view, when baseline sampling shows little or no evidence of the presence of dehalorespirators or active reductive dechlorination. However, ERD can be achieved in these situations through the creation and maintenance of the ideal redox conditions, coupled with a long term supply of terminal electron donors. Regenesis has successfully remediated many sites via ERD, where initial conditions appear unpromising, using Hydrogen Release Compound (HRC) and 3-D Microemulsion (3DMe) substrate technologies. This case study exemplifies this approach and presents data from a site where treatment is ongoing.